REGENERATIVE MEDICINE CROSSING BORDERS

RegMed XB Organization

Scientific Board:
Prof. Clemens van Blitterswijk, Prof. Hans Clevers, Prof. Bert Meijer, Prof. Ton Rabelink, Prof. Frank Luyten, Prof. Peter Carmeliet
Moonshot Leaders:
Eelco de Koning (diabetes), Ton Rabelink (kidney) and Keita Ito (osteoarthritis)
Foundation and Executive Team:
Marianne van der Steen (director)
Vanessa LaPointe (scientific coordinator), Program Management
Mike Shaw and Jeanine Hendriks (valorization phase 1), Office management
Director:
Prof. Marianne van der Steen
RegMed XB office:
Contact person: Romina Gentier.
Tel: +31 6 48 45 97 98
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Why regenerative medicine?

The prevalence of chronic disease worldwide is rapidly increasing. Regenerative medicine aims to restore degenerated, diseased, or damaged tissues and organs, thereby increasing vital functioning and reducing the cost of healthcare. Regenerative medicine holds the promise to cure many chronic conditions, restoring health rather than protracting decline, bettering the lives of millions and at the same time preventing lifelong, expensive care processes: cure instead of care. RegMed XB brings together health foundations, scientists, entrepreneurs and governments to cooperatively tackle ambitious challenges in regenerative medicine. The partners include leading researchers and entrepreneurs with decades of world leading experience in regenerative medicine.

What is RegMed XB?

RegMed XB stands for Regenerative Medicine Crossing Borders. It is a virtual institute of Dutch and Belgian public (universities and governments) and private (health foundations and companies) partners that will work together to develop regenerative medicine solutions to health challenges. At the moment, RegMed XB is in its "Phase 1" stage and we are looking to expand the programme to more topics in musculoskeletal disease (e.g. osteoarthritis) cardiovascular disease, and organ regeneration. We believe that when researchers and entrepreneurs work side by side, we stand the best chance to bring the most impact to patients and society at large.

What is Phase 1?

We are currently in Phase 1 of RegMed XB. In Phase 1, we have three scientific objectives. The first objective is to bring a new therapy for type I diabetes into a human trial, involving pancreatic β-cells that can produce insulin in response to blood sugar without the need for immunosuppressive agents. The second objective is to create a bioengineered kidney subunit to take a major step towards an artificial kidney replacement. And the third objective is to create a model of osteoarthritis to predict which patients will require surgical intervention and to lay the groundwork for a new therapy. The first phase of RegMed XB is expected to begin in the first quarter of 2017. It is a five-year programme.

Who are we?

RegMed XB collaborates on ambitious projects in the field of regenerative medicine. The partners in the collaboration are health foundations, universities, regional governments, and companies. In Phase 1, four health foundations (Nierstichting, Diabetes Fonds, Diabetes Onderzoek Nederland, and Reumafonds) join to define the research objectives and co-govern the project to keep a focus on the end-goals that improve patients' lives. Scientists from four universities (Leiden University, Utrecht University/Hubrecht Institute, Eindhoven University of Technology, and Maastricht University) join to bring in and further develop their proven technology and expertise that can be applied to challenges set by the health foundations. Companies join to share expertise and facilities, provide materials and personnel, and work as valorization instruments. And finally, four regions (Leiden, Utrecht, Noord-Brabant, and Limburg) join to support both the research and its valorization, thereby creating new jobs and businesses. RegMed XB is expected to expand to include partners in Flanders and other health foundations.

Why are the partners working together?

Our mission is to create more of an impact from science. The success of the emerging regenerative medicine sector relies on excellent research at knowledge institutes and effective valorization thereof. The partners are chosen because they punch above their weight in excellent science and they have a solid infrastructure for translation with university medical centers. They also possess the multidisciplinary knowledge that is required for regenerative medicine. Together, we want to develop the emerging regenerative medicine industry to create jobs and solutions for patients. In the future, we will also form a dedicated team to support valorization.

Working with RegMed XB


Postdoc On-chip kidney interaction model

The project of this position aims to develop a microfluidics-based model that forms a minimal representation of kidney function and which can be used to get insight into processes relevant for kidney regeneration. The model will follow a development towards integrating more complexity if needed to realize kidney function. The postdoctoral researcher will design and fabricate the microfluidic device, establish a cell co-culture within the device representative of the basic nephron function, and characterize the obtained in-vitro model e.g. characterizing morphology, active transport, and using biological readouts.
Closing date: 01/12/2017

 

PhD candidate in Lubrication and Wear of Osteochondral Implants
We aim to develop a functional regenerative osteochondral implant using a multi-disciplinary approach with various academic centres and industries. One part of the development is to optimize lubrication of the implant and therewith to minimize friction and wear of the cartilage that slides over the implant. This project will be performed in close collaboration with Fujifilm, who is developing lubricating coatings. Measurements will be performed using commercial and home-made tissue-level testing equipment, as well as using a total joint tester. Some further development of the equipment may be required for particular purposes during the project.
Screening of applicants will start as soon as applications are received and will continue until the position has been filled.

 

PhD candidate in Mechanical Optimization of Osteochondral Implants
We aim to develop a functional regenerative osteochondral implant using a multi-disciplinary approach with various academic centres and industries. One part of the development is to assemble the construct using hydrogels developed at Utrecht University and a fibrous developed in Aachen. This includes developing ways to assemble the hydrogel, cells and scaffolds into a construct, as well as the mechanical characterization thereof. Subsequently, directions for optimization of the mechanical properties will be identified, such that the material ultimately matches the properties of the bone and cartilage it will replace. As these suggestions for optimization involves other parts of the project, there will be close interaction with the entire team.
Screening of applicants will start as soon as applications are received and will continue until the position has been filled.

  • Diabetes FondsDiabetes Fonds
  • Leids Universitair Medisch CentrumLeids Universitair Medisch Centrum
  • Provincie UtrechtProvincie Utrecht
  • RijksoverheidRijksoverheid
  • Health HollandHealth Holland
  • Maastricht UMC+Maastricht UMC+
  • Provincie LimburgProvincie Limburg
  • TU/eTU/e
  • NierstichtingNierstichting
  • Provincie Noord-BrabantProvincie Noord-Brabant
  • Universiteit LeidenUniversiteit Leiden
  • LeidenLeiden
  • Stichting DONStichting DON
  • ReumafondsReumafonds
  • Maastricht UniversityMaastricht University
  • UMC UtrechtUMC Utrecht
  • Utrecht UniversityUtrecht University
  • KU LeuvenKU Leuven
  • VIBVIB

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